Methoxyflurane

Trade Name: Penthrox

Uses

  • Short-term relief of moderate to severe acute pain associated with trauma or interventional medical procedures

Adverse Effects

  • Dizziness
  • Headache

Considerations for PT

  1. Primarily used for short-term pain relief, unlikely to be used in conjunction with physiotherapeutic intervention

Route of Administration

  1. Inhalation

Mechanism of Action

Acts by inhibiting pain signaling in the central nervous system to produce analgesic effects.

Drug Dynamics

Time to Peak Effect

5 minutes to 45 minutes

Duration of Action

25 minutes to 60 minutes

Time to Onset

1 minute to 5 minutes

Resources

*Some links accessed via VCH Intranet

Last updated: July 16, 2026