Tramadol

Trade Names: Durela, Ralivia, Tridural, Zytram XL

Uses

  • Analgesia (severe and persistent pain)
  • Premature ejaculation

Adverse Effects

Considerations for PT

  1. Consider risk of dizziness and drowsiness and potential impact on falls risk.Consider risk of dizziness and drowsiness and potential impact on falls risk.
  2. Consider timing for pain relief prior to Physiotherapy intervention Consider timing for pain relief prior to Physiotherapy intervention

Route of Administration

  1. Oral (Extended Release)
  2. Oral (Immediate Release)

Mechanism of Action

Binds to opioid receptors in the central nervous system, causing:

  • Inhibition of ascending pain pathways
  • Alteration of pain perception
  • Alteration of response to pain
  • Modulates action of descending inhibitory pain pathway

Drug Dynamics

Time to Peak Effect

10 hours to 12 hours

Duration of Action

12 hours to 24 hours

Time to Onset

1 hour to 2 hours

Last updated: April 1, 2026